Is there a limit to expansion of the International Space Station?

If there was the funding and desire to continue using the ISS, would there be hard engineering limitations on the maximum size of habitable space that could be attached to it, or could the existing ISS be used (in theory) as a "backbone" to grow and expand on?
A rearward view of the International Space Station backdropped by the limb of the Earth.

Although spacecraft could be almost arbitrarily large, the ISS is also part aircraft, and limitations apply there.

The ISS operates at an altitude where there is still a thin atmosphere to contend with, and the main cause of orbital decay for the ISS is atmospheric drag. To counter this, the ISS enters Night Glider Mode, reorienting its solar arrays to minimize atmospheric drag when the ISS is shaded from the Sun by the Earth.

So the limit would be the point where atmospheric drag increases to a point where the orbital decay it causes can't be overcome by reboost from visiting (propelled) spacecraft.

Has it been scientifically proven that Nuclear Fusion is actually a possibility and not a 'golden egg goose chase'?
How much more dangerous would lightning strikes have been 300 million years ago when atmospheric oxygen levels peaked at 35%?

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